Metabolism of Flavin Nucleotides. II. Decomposition of Flavin Nucleotides in the Small Intestine.

Assay of flavin nucleotides in pancreatic islets by a differential fluorimetric technique.

Differences in fluorescence intensity between FMN and FAD at high and low pH values were utilized to determine the concentration of each nucleotide. Amounts down to 1 pmol were measurable. The FMN and FAD contents of pancreatic islets of obese-hyperglycaemic mice (gene symbol ob/ob) were compared with those of the exocrine pancreas, the liver and heart muscle. As expected, the FAD content of ea...

Pyridine nucleotides in erythrocyte metabolism.

Flavin Containing Monooxygenases and Metabolism of Xenobiotics

Bu derlemede flavin-içeren monooksijenazların (FMO) farmakolojik ve toksikolojik önemi ile ilgili güncel bilgiler özetlenmiştir. FMO’lar nükleofilik hetereatom içeren ksenobiyotiklerin ve ilaçların oksidasyonuna katılan mikrozomal bir enzim ailesidir. FMO’ların ilaç metabolizmasındaki etkinlikleri ve hastalıklarla olan ilişkileri, daha fazla araştırılması gereken alanlardır. FMO’lar üzerine yap...

Flavin metabolism during respiratory infection in mice.

Previous control studies carried out in children showed that respiratory infection alters riboflavin metabolism and leads to excessive urinary losses of the vitamin. In order to understand the nature of biochemical changes in riboflavin metabolism during respiratory infection, a study was carried out using the mouse as the experimental model, and Klebsiella pneumoniae as the infective organism....

FLX1 codes for a carrier protein involved in maintaining a proper balance of flavin nucleotides in yeast mitochondria.

Respiratory defective mutants of Saccharomyces cerevisiae previously assigned to complementation group G178 are characterized by an abnormally low ratio of FAD/FMN in mitochondria. A nuclear gene, designated FLX1, was selected from a yeast genomic library, based on its ability to confer wild-type growth properties to a representative G178 mutant. Genetic evidence has confirmed that the flavin n...